Immune system
VIP (Vasoaktives Intestinales Peptid)
Also known as: VIP-27
An endogenous 28-amino-acid neuropeptide from the nervous system and gut. VIP activates the VPAC1 and VPAC2 receptors and is used in research on cAMP signalling, immune modulation and the enteric nervous system.
Structure
- Sequence
- His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn
- Molecular formula
- C₁₄₇H₂₃₈N₄₄O₄₂S
- Molecular weight
- 3326.80 Da
- Amino acids
- 28
Mechanism of action
VPAC1/VPAC2 agonist that activates the adenylate cyclase/cAMP cascade and modulates inflammatory cytokine signalling in immune cell models.
More in Immune system
More detail (research areas, comparisons, FAQ): German lexicon entry.