Regeneration
TB-500
Also known as: Thymosin Beta-4 Fragment, Tβ4
A synthetic peptide corresponding to the active region of thymosin beta-4. TB-500 is studied in tissue regeneration, wound healing and cell migration research.
Structure
- Sequence
- Fragment von Thymosin β4 (43 amino acids)
- Molecular formula
- C₂₁₂H₃₅₀N₅₆O₇₈S
- Molecular weight
- 4,921 Da
- Amino acids
- 43
- Half-life
- ~2 hours
Mechanism of action
TB-500 binds G-actin and prevents its polymerisation, which promotes cell motility and migration. In models it also lowers pro-inflammatory cytokines and promotes angiogenesis.
Studies
More in Regeneration
More detail (research areas, comparisons, FAQ): German lexicon entry.