Regeneration
ACE-031 (ActRIIB-Fc)
Also known as: ActRIIB-Fc, Ramatercept
A recombinant fusion protein of the extracellular domain of the activin type IIB receptor (ActRIIB) and the Fc part of human IgG1. It binds myostatin, activin A and GDF-11 and so blocks their signalling.
Structure
- Sequence
- Rekombinantes Fusionsprotein: ActRIIB-ECD–Fc (IgG1)
- Molecular formula
- Glykoprotein, rekombinant
- Molecular weight
- ~60,000 Da
- Amino acids
- ~500 (Fc-Fusion)
Mechanism of action
An ActRIIB ligand trap that inhibits myostatin, GDF-11 and activin signalling and modulates muscle mass in preclinical models.
More in Regeneration
More detail (research areas, comparisons, FAQ): German lexicon entry.